ADmit Therapeutics is a biotechnology company founded at the end of 2017 as a spin-off from the Bellvitge Biomedical Research Institute (IDIBELL). The company is focused on the development and commercialization of a new early detection technology for Alzheimer's disease (AD) and has successfully closed a €5.4 million equity round.
ADmit has secured a €5.4 million equity round with Clave Capital as the lead investor, with significant support from the EIC Fund and the Alzheimer's Drug Discovery Foundation (ADDF) Diagnostics Accelerator (DxA), alongside other investors such as Lavanda Ventures, Ship2B and WA4Steam. This funding round will enable the company to obtain CE marking and FDA approval for the commercialization of MAP-AD in Europe and the United States.
MAP-AD, the technology, is based on an algorithm capable of stratifying Mild Cognitive Impairment (MCI) patients based on their probability of progressing to AD dementia (ADD) through the epigenetic analysis of mitochondrial DNA (mtDNA) methylation signatures in a patient's blood sample. The innovative approach of MAP-AD lies in these disruptive findings, a combination of patented biomarkers based on mtDNA methylation patterns and a novel algorithm to link the pattern with the clinical prognosis of ADD.
The use of MAP-AD technology by pharmaceutical companies to optimize patient selection has the potential to reduce the time and costs associated with clinical trials, increasing the likelihood of identifying new effective therapies for AD.
There is a clear need for individualized prognosis of MCI progression to ADD. Timely and accurate diagnosis of AD impacts the quality of life of patients and their families by allowing for timely and optimized treatment.
Marta Barrachina, CEO of ADmit, highlighted: "Our unique value proposition allows us to calculate the probability of a patient with MCI progressing to AD with just a blood sample and using state-of-the-art sequencing techniques. This enables clinicians to optimally stratify patients and prescribe the best treatment."
From Clave, "we highly value the results achieved to date, the diagnostic capability in very early stages of neurodegenerative diseases such as Alzheimer's and others, in a highly prevalent and growing market where innovative therapies are emerging," said Santiago Lozano, Director of Funds and Clave Innohealth f.c.r. Giacomo de Simone, a board member at Clave, particularly appreciates the scientific capabilities of the team led by Marta and the disruptive potential that this technology could have in the clinical field.
About Clave Capital: Clave Capital is an independent alternative asset management firm specializing in innovative projects and industrial SMEs. The firm has significant expertise in creating business value from scientific research results, with over 20 years of experience in investing in, building, and supporting technology projects from their early stages, with a clear focus on technology transfer. Currently, it manages more than €90 million directed towards innovative projects, with a prominent fund of €50 million, Clave Innohealth f.c.r., promoted with the support of CDTI Innvierte and several private investors linked to the healthcare sector.
About the EIC Fund: The European Innovation Council Fund from the European Commission is an agnostic Fund: it invests across all technologies and verticals, and all EU countries and countries associated to Horizon Europe. It provides the investment component of the EIC Accelerator blended finance.
The EIC Fund aims to fill a critical financing gap and its main purpose is to support companies in the development and commercialisation of disruptive technologies, bridging with and crowding in market players, and further sharing risk by building a large network of capital providers and strategic partners suitable for co-investments and follow-on funding.
The Fund pays particular attention to the empowerment and support of female founders as well as the ambition to reduce the innovation divide among EU countries.
About The Diagnostics Accelerator (DxA): The Diagnostics Accelerator, created in July 2018, is a $100 million global research initiative from partners including ADDF Co-Founder Leonard A. Lauder, Bill Gates, Jeff Bezos, MacKenzie Scott, the Dolby family, the Charles and Helen Schwab Foundation, The Association for Frontotemporal Degeneration, among others, to develop novel biomarkers for the early detection of Alzheimer's disease and related dementias.
This research initiative is dedicated to accelerating the development of affordable and accessible biomarkers to diagnose Alzheimer's disease and related dementias and advance the clinical development of more targeted treatments. Through translational research awards and access to consulting support from industry experts, this program will challenge, assist and fund the research community in both academia and industry to develop novel peripheral and digital biomarkers.
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